Table 3.
Over‐represented GO terms for FGF2‐upregulated genes in murine microvascular 1G11 cells
| GO term | Number of genes | % | Statistical significance |
|---|---|---|---|
| Molecular function | |||
| Receptor binding | 34 | 12.1 | 1.0E‐07 |
| Growth factor activity | 18 | 6.4 | 1.1E‐07 |
| Cytokine activity | 19 | 6.8 | 2.5E‐06 |
| Cellular component | |||
| Extracellular space | 69 | 24.6 | 2.5E‐04 |
| Extracellular region | 71 | 25.4 | 5.8E‐04 |
| Basolateral plasma membrane | 6 | 2.1 | 6.0E‐03 |
| Extracellular matrix | 10 | 3.6 | 5.2E‐02 |
| Biological process | |||
| Blood vessel morphogenesis | 19 | 6.8 | 2.2E‐09 |
| Angiogenesis | 16 | 5.7 | 4.5E‐08 |
| Ossification | 13 | 4.6 | 2.0E‐07 |
| Bone mineralization | 8 | 2.9 | 3.8E‐05 |
| Regulation of bone remodelling | 7 | 2.5 | 2.7E‐05 |
| Inflammatory response | 12 | 4.3 | 4.4E‐04 |
FGF2‐upregulated genes (see Table 2 for the detailed list of these genes) were classified in terms of their associated GO molecular functions, cellular components and biological processes. The most over‐represented GO terms, the number and percentage of genes belonging to each category, and the statistical significance are shown.