Table.
Summary of weighted amenorrhea prevalence measures in percentage of levonorgestrel intrauterine system users for 4 90-day intervals and the first year after insertion
| Interval | Total participants across studies, n | Random effect, % (95% confidence interval) | I2, % (95% confidence interval) | Included studies, n | Degrees of freedom | P value |
|---|---|---|---|---|---|---|
| Days | ||||||
| 0–90 | 1868 | 0.2 (0.0–0.4) | 0.0 | 4 | 3 | .893 |
| 91–180 | 2748 | 8.1 (6.6–9.7) | 37.6 (0.0–75.2) | 6 | 5 | .155 |
| 181–271 | 1665 | 13.6 (9.3–18.0) | 64.0 (0.0–87.8) | 4 | 3 | .039 |
| 272–365 | 1565 | 20.3 (13.5–27.0) | 76.4 (35.4–91.4) | 4 | 3 | .005 |
| Month 0–12 | 1740 | 18.2 (14.9–21.5) | 30.6 (0.0–76.2) | 3 | 2 | .237 |
Sergison and Maldonado. Amenorrhea associated with LNG-IUS use. Am J Obstet Gynecol 2019.