Table. Different Hepatitis C Virus Testing Algorithms Evaluated to Scale Up Interventions in Pakistan^a.

Testing Algorithm	Screening Test	Detection of Viremia	Assessment of Hepatitis C Treatment Response
T1 (base case)	Laboratory based	Nucleic acid test	Nucleic acid test
T2	Laboratory based	HCVcAg test	Nucleic acid test
T3	Point of care	Nucleic acid test	Nucleic acid test
T4	Point of care	GeneXpert	GeneXpert
T5	Point of care	HCVcAg test and nucleic acid test if HCVcAg test result is negative	HCVcAg test
T6	Point of care	HCVcAg test and nucleic acid test if HCVcAg test result is negative	Nucleic acid test
T7	Laboratory based	GeneXpert	GeneXpert

Abbreviation: HCVcAg, hepatitis C virus core antigen.

^aPerformance characteristics of each test are as follows: point-of-care screening, 99.5% sensitivity and 99.8% specificity; nucleic acid test, 99.8% sensitivity and 99.7% specificity; GeneXpert, 99.8% sensitivity and 99.7% specificity; HCVcAg test, 93.2% sensitivity and 98% specificity; and HCVcAg test and nucleic acid test if HCVcAg test result is negative, 99.8% sensitivity and 99.8% specificity.