Table 3. Adverse Neonatal Outcomes for Infants Born to Women With Different Subtypes of ACHD in Canada From Fiscal Years 2001-2002 to 2014-2015^a.

Participant Group	Outcome
	Severe Neonatal Morbidity and Mortality			Perinatal Mortality			Major Visible Congenital Anomalies
	No. (%) [95% CI, %]	OR (95%CI)		No. (%) [95% CI, %]	OR (95%CI)		No. (%) [95% CI, %]	OR (95%CI)
		Crude	Adjustedb		Crude	Adjustedb		Crude	Adjustedb
All infants of women without ACHD	140 307 (5.2) [5.2-5.3]	1 [Reference]	1 [Reference]	6593 (0.2) [0.2-0.3]	1 [Reference]	1 [Reference]	17 197 (0.6) [0.6-0.7]	1 [Reference]	1 [Reference]
All infants of women with any type of ACHD	241 (11.4) [10.1-12.8]c	2.3 (2.0-2.6)c	1.8 (1.6-2.1)c	17 (0.8) [0.5-1.3]c	3.2 (2.0-5.2)c	2.6 (1.6-4.3)c	27 (1.3) [0.9-1.9]c	2.0 (1.3-3.0)c	1.9 (1.3-2.8)c
Infants of women with a subtype of ACHD
Heterotaxy	9 (21.4) [11.4-36.5]c	4.8 (2.3-10.1)c	4.3 (1.9-9.5)c	NAd	NAd	NAd	NAd	NAd	NAd
Anomalies of venous return	35 (8.5) [6.2-11.7]c	1.7 (1.2-2.4)c	1.2 (0.9-1.8)	NAd	NAd	NAd	7 (1.7) [0.8-3.5]c	2.7 (1.3-5.7)c	2.5 (1.2-5.2)c
Anomalies of the atria and interatrial communications	35 (8.7) [6.3-11.8]c	1.7 (1.2-2.4)c	1.3 (0.9-1.8)	NAd	NAd	NAd	7 (1.7) [8.3-3.6]c	2.7 (1.3-5.7)c	2.5 (1.2-5.3)c
Anomalies of atrioventricular junctions and valves	110 (7.6) [6.4-9.1]c	1.5 (1.2-1.8)c	0.9 (0.7-1.1)	7 (0.5) [0.2-1.0]	1.9 (0.9-4.1)	0.9 (0.4-2.0)	12 (0.8) [0.5-1.5]	1.3 (0.7-2.3)	1.1 (0.6-2.0)
Complex anomalies of atrioventricular connections	19 (19.4) [12.7-28.5]c	4.3 (2.6-7.2)c	4.1 (2.4-6.9)c	NAd	NAd	NAd	NAd	NAd	NAd
Functionally univentricular hearts	32 (21.2) [15.4-28.5]c	4.8 (3.2-7.1)c	4.4 (2.9-6.6)c	NAd	NAd	NAd	NAd	NAd	NAd
Ventricular septal defects	34 (10.0) [7.2-13.6]c	2.0 (1.4-2.9)c	1.7 (1.2-2.4)c	NAd	NAd	NAd	6 (1.8) [0.8-3.9]c	2.8 (1.2-6.2)c	2.6 (1.2-5.8)
Anomalies of the ventricular outflow tracts	113 (11.9) [10.0-14.1]c	2.4 (2.0-3.0)c	2.0 (1.6-2.4)c	5 (0.4) [0.2-1.3]	2.1 (0.9-5.2)	1.8 (0.7-4.4)	9 (0.9) [0.5-1.8]	1.5 (0.8-2.9)	1.4 (0.7-2.7)
Anomalies of the extrapericardial arterial trunks	37 (9,0) [6.6-12.1]c	1.8 (1.3-2.5)c	1.4 (1.0-2.0)	NAd	NAd	NAd	5 (1.2) [0.5-2.9]	1.9 (0.8-4.6)	1.8 (0.7-4.3)
Congenital anomalies of the coronary arteries	19 (17.6) [11.5-26.0]c	3.8 (2.3-6.2)c	3.8 (2.3-6.2)c	NAd	NAd	NAd	NAd	NAd	NAd

Abbreviations: ACHD, adult congenital heart disease; NA, not applicable; OR, odds ratio.

^aExcludes Quebec.

^bAdjusted for Obstetric Comorbidity Index, mode of delivery, and year of birth.

^cP < .05 for comparison of infants born to women with and without ACHD and infants born to women with specific subtypes of ACHD and women without ACHD.

^dSample size less than 5.