Table 2.
Reproductive and oncological outcomes of CAH/early-stage EC patients who treated with fertility-preservation procedure
| Study | CR | Time of achieving CR(m) | PR or SD | PD | Recurrence | Time to recurrence(m) | Pregnancy | Gestational mode | Live birth | Hysterectomy | Follow-up time(m) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tamauchi 201819 | CAH: n=28 | CAH:26 (10–63) | 3 | UK | CAH: n=14 | CAH: 72 (10–283) | 14 | IVF: n=10; | 7 | 3 | 52 (16–128) |
| EC: n=8 | EC:40 (26–53) | EC: n=7 | EC: 50 (24–272) | Spontaneous: n=4 | 3 | ||||||
| Fukui 201720 | 25 | UK | 10 | 0 | 8 | UK | 12 | UK | 11 | 15 | 89 (12–193) |
| Hwang 201721 | 3 | 11.0 (6–18) | 2 | 0 | 1 | 23 | 1 | IVF | 0 | 2 | 44.4 (12–71) |
| Park 201722 | 111 | 4.5 (0.8–55.5) | UK | UK | 43 | 57 (6–194) | 45 | UK | 35 | UK | 57 (6–194) |
| Kim 201723 | 22 | UK | 28 | 0 | 3 | UK | 10 | IVF: n=7; Others: n=3 |
5 | 27 | 23 (3–118) |
| Chen 201624 | CAH: n=12 | 6 (3–24) | 10 | 4 | CAH: n=3 | 28.5 (4–56) | 17 | IVF | 11 | 20 | 54 (4–148) |
| EC: n=27 | EC: n=7 | ||||||||||
| Baek 201625 | CAH: n=16 | CAH:3 (1–22) | 8 | 0 | CAH: n=2 | 8 (7–11) | 2 | ART | 2 | 8 | 11.5 (3–29) |
| EC: n=7 | EC 3 (2–9) | EC: n=4 | 2 (4–18) | ||||||||
| Zhou 201526 | 27 | 6.2 (0.8–41.5) | 5 | 0 | 9 | 8.5 (3–17.3) | 9 | ART | 5 | 2 | 32.2 (10–92) |
| Pronin 201514 | CAH: n=35 | UK | 9 | 0 | CAH: n=1 | 6–12 | 8 | Spontaneous | 8 | 9 | 17 (1–45) |
| EC: n=23 | EC: n=2 | ||||||||||
| Mitsuhashi 201527 | 29 | 6–9 | 5 | 2 | 3 | 38 (1–66) | 8 | IVF | 6 | 4 | 38 (9–66) |
| Simpson 201428 | 24 | 5.7 (2–24) | 20 | 0 | 13 | 42 | 5 | IVF: n=4; Spontaneous: n=1 |
2 | 21 | 39 (5–128) |
| Kudesia 201413 | CAH: n=5 | 13 (3–74) | 9 | 0 | UK | UK | 4 | IVF | 4 | 7 | 13 (3–74) |
| EC: n=7 | |||||||||||
| Gonthier 201429 | 29 | 2–6 | UK | UK | 6 | 3–37 | 14 | ART: n=9; Spontaneous: n=5 |
10 | UK | 23.4 (6–130) |
| Park 201312 | 115 | 4.5 (2–13.8) | 33 | 0 | 35 | 15 (4–61) | 44 | UK | 44 | 13 | 66 (14–194) |
| Jafari 201330 | 7 | 6 (3–9) | 1 | 0 | 3 | 14 (3–21) | 3 | IVF: n=2 | 2 | 3 | 34.5 (11–72) |
| Koskas 201231 | CAH: n=12 | 4.4 1(3–6) | 4 | 1 | 3 | 15.3 (6–31) | 8 | UK | 8 | 6 | 39 (14–86) |
| EC: n=5 | |||||||||||
| Fujiwara 201215 | 36 | 6.2 (3.3–17.5) | UK | UK | 17 | 12 (7–84) | UK | UK | UK | UK | 66 (11–251) |
| Ricciardi 201232 | 11 | UK | 3 | 0 | UK | UK | 4 | IVF | 4 | 3 | UK |
| Perri 201133 | 24 | 5 (1–17) | 3 | 0 | 9 | 39.9 (1.8–84) | 14 | IVF: n=9; Spontaneous: n=5 |
10 | 10 | 57.4(7.8–412) |
| Park 201134 | 13 | 6 (3–15) | 1 | 0 | 2 | 7–36 | 4 | ART: n=4 | 4 | 1 | 47.3(18–135) |
| Kim 201118 | 4 | 5 (3–12) | 1 | 0 | 0 | —— | 1 | IVF | 1 | 0 | 10.2(6–16) |
| Minig 201035 | CAH: n=19 | 6–12 | 2 | 5 | CAH: n=4 | 36 (16–62) | 9 | UK | 7 | 13 | 29 (4–102) |
| EC: n=8 | EC: n=2 | ||||||||||
| Yu 200936 | 19 | CAH: 7.3(3–11) | 6 | 0 | 4 | CAH: 30 | 4 | IVF: n=3; Spontaneous: n=1 |
4 | 6 | CAH: 34.6 (7–114) |
| EC: 6.4 (3–10) | EC:11 (6–16) | EC: 31.8(5–90) | |||||||||
| Han 200937 | 10 | 5.2 (3–18) | 0 | 0 | 1 | UK | 9 | ART | 6 | 1 | 46.8 (13–75) |
| Hahn 200938 | 22 | 9 (2–12) | 13 | 0 | 9 | 12 (8–48) | 10 | ART: n=7; Spontaneous: n=3 |
8 | 16 | 39 (5–108) |
| Signorelli 200839 | 3 | 4 (3–9) | 18 | 0 | UK | UK | 9 | UK | UK | 9 | 98 (35–176) |
| Yamazawa 200740 | 8 | 5.3 (3–9) | 0 | 0 | 2 | 16 (10–22) | 4 | ART: n=4 | 3 | 2 | 39 (24–69) |
| Ushijima 200717 | CAH: n=16 | 12.5 (8–26) | 13 | 0 | 14 | CAH: 44.2 | 11 | ART: n=10; Spontaneous: n=1 |
7 | 18 | 39 (5–128) |
| G1EC: n=14 | EC: 34.6 | ||||||||||
| Yang 200541 | 4 | 3.5 (2–5) | 2 | 0 | 2 | 4.5 | 2 | UK | 2 | 4 | 48.8(14–132) |
| Yahata 200542 | 7 | 8.7 (4–14) | 1 | 0 | 7 | 11.6 (4–33) | 3 | ART: n=3 | 3 | 5 | 76.5(21–118) |
| Gotlieb 200342 | 11 | 3.5 (0–9) | 0 | 0 | 5 | 40 (19–358) | 6 | UK | 3 | 4 | 82 (6–358) |
Abbreviations: ART, assisted reproductive technology; IVF, in-vitro fertilization; IK unknown.