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. 2019 May 8;15:1211–1229. doi: 10.2147/NDT.S204818

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© 2019 Wei et al.

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Fat-bingeing increases the motivation for palatable food, but chronic stress enhances the outcomes. In our motivation test, we suspended the food above the floor of the light box. The activity trajectories of the mice were analyzed by reprocessing the video recordings (A). Upon exposure to the chow food signal, there were no significant differences among groups (B). Upon exposure to the chow food signal, mice in fat-bingeing group and chronic stress/fat-bingeing group spent more time in the light box (C). Fat-bingeing increases craving for palatable food after fasting (D). Time in the light box in the presence of the palatable food (E) but not chow food (F) was positively correlated with the craving for palatable food. * denotes significant differences between chow group and due group; # denotes significant differences between chronic stress group and due group (*P<0.05; **P<0.01; ^##P<0.01^###P<0.001).