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. 2019 Apr 26;10:277. doi: 10.3389/fpsyt.2019.00277

Figure 1.

Figure 1

Chronic social defeat stress (CSDS) induces social avoidance and adrenal hypertrophy without changes in basal corticosterone levels. Body weight throughout the stress procedure did not differ between groups (A). Following CSDS, susceptible mice spent significantly less time investigating a novel CD1 mouse than an empty cage in the social interaction (SI) test (B) and significantly decreased the SI ratio in susceptible and increased SI ratio in resilient mice compared to controls (C). CSDS did not alter body weight at 2 or 8 days following the final defeat (D) but induced an increase in adrenal weight in both susceptible and resilient mice at 2 days but not 8 days (E) with no changes in basal corticosterone (F). ***p < 0.001, two-way repeated measures (RM) ANOVA with Sidak post hoc comparisons; *p < 0.05, susceptible and resilient groups compared to control, one-way ANOVA with Sidak post hoc comparisons.