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. 2019 Apr 26;10:277. doi: 10.3389/fpsyt.2019.00277

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Copyright © 2019 Dick, Khermesh, Paul, Stamp, Levanon and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CSDS acutely alters transcripts encoding adenosine deaminases acting on RNA (ADARs) within the medial prefrontal cortex (mPFC) of susceptible mice. Following CSDS, no changes in Adar, Adarb1, or Adarb2 mRNA levels were observed within the basolateral amygdala (BLA) at 2 days (A) or 8 days (B). CSDS significantly decreased the expression levels of Adar variant 2 (p150) and Adarb1 mRNA in the mPFC only in mice susceptible to the CSDS procedure (C). No changes were observed within the mPFC 8 days following CSDS (D). Control 2 days, n = 7; susceptible 2 days, n = 10; resilient 2 days, n = 4; control 8 days, n = 5–7; susceptible 8 days, n = 7; resilient 8 days, n = 3. *p < 0.05, one-way ANOVA with Sidak post hoc comparisons.