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. 2019 May 10;14:3245–3263. doi: 10.2147/IJN.S179202

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© 2019 Romero-Ben et al. This work is published and licensed by Dove Medical Press Limited

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Synthetic pathway for the synthesis of derivatives 11 and 12.

Notes: (a) Boc₂O, THF, 54%; (b) see ref 36; (c) CuSO₄, sodium ascorbate, CH₂Cl₂/H₂O, MW, 7 (62%), 8 (80%); (d) TFA, CH₂Cl₂, 9 (99%), 10 (80%); (e) MeONa/MeOH, 11 (79%), 12 (60%).

Abbreviations: THF, tetrahydrofuran; MW, microwave; TFA, trifluoroacetic acid.