Table 1.
Formulae of simvastatin polymeric nanoparticles
| Formulae | SIM (mg) | Polymer | Solvent | D:P (molar ratio) | Cosolvent | Stabilizer (mg) |
|---|---|---|---|---|---|---|
| F1 | 10 | PVP K-90 | Acetone | 1:1 | – | 1 MC |
| F2 | 10 | 1:2 | – | |||
| F3 | 10 | 1:3 | – | |||
| F4 | 10 | Methylene chloride | 1:1 | – | 1 ST + 1 Na. D | |
| F5 | 10 | 1:2 | – | |||
| F6 | 10 | 1:3 | – | |||
| F7 | 10 | PEG 4000 | Acetone | 1:1 | Glycerol (10 mL) | – |
| F8 | 10 | 1:2 | – | |||
| F9 | 10 | 1:3 | – | |||
| F10 | 10 | 1:1 | – | 1 MC | ||
| F11 | 10 | 1:2 | – | |||
| F12 | 10 | 1:3 | – | |||
| F13 | 10 | Methylene chloride | 1:1 | – | 1 ST + 1 Na. D | |
| F14 | 10 | 1:2 | – | |||
| F15 | 10 | 1:3 | – | |||
| F16 | 10 | 1:4 | Glycerol (10 mL) | – | ||
| F17 | 10 | 1:5 | – | |||
| F18 | 10 | 4:2 PEG 4000: PVP K-90 | Methylene chloride | 1:4:2 | – | |
| F19 | 30 | PEG 4000 | Acetone | 1:3 | – | |
| F20 | 20 | 1:3 | – | |||
| F21 | 40 | 1:3 | – | |||
| F22 | 50 | 1:3 | – | |||
| F23 | 30 | 4:3 PEG 4000: PVP K-90 | Methylene chloride | 1:4:3 | – | |
| F24 | 30 | 4:4 PEG 4000: PVP K-90 | 1:4:4 | – |
Abbreviations: PVP K-90, polyvinylpyrrolidone K-90; PEG 4000, polyethylene glycol 4000; SIM, simvastatin; MC, methyl cellulose; ST, stearic acid; Na. D, sodium deoxycholate.