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. 2019 Feb 22;11(3):606–620. doi: 10.1080/19420862.2019.1578147

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 8. — Comparison of Tier 2 Fab and Fc related binding functions of HLX01, CN-rituximab and EU-rituximab. The dot plots of (a) FcγRIa binding affinity, (b) FcγRIIa binding affinity, (c) FcγRIIb/c binding affinity, (d) FcγRIIIa-F binding affinity, (e) FcγRIIIa-V biding affinity, (f) FcγRIIIb binding affinity, (g) C1q binding affinity, (h) ADCC activity, (i) Apoptosis activity. Each marker shows the activity value of a specific batch: the blue dots show the values of CN-rituximab, red triangles show the values of HLX01, and black squares show the values of EU-rituximab. Dashed lines represent quality range according to the suggestion of FDA (mean ± 3 SD).