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Changes in DEPC modification extents after the heat stress at 65°C for 4 h. The pie charts indicate the fraction of modified residues that undergo statistically significant labeling changes within each domain of rituximab. Red represents labeling increases while blue represents decreases. The bar charts for each domain indicate the number of residues whose extent of covalent labeling (CL) change falls within low (L), medium (M), and high (H) bins.
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