Second messenger cGMP generation in normal canines treated with ANG1-7, BNP and NPA7; † P<0.05 vs BNP, #P<0.05 vs ANG1-7, *P<0.05 vs baseline; ††P<0.01 vs BNP, ##P<0.01 vs ANG1-7, **P<0.01 vs baseline ; †††P<0.001 vs BNP, ###P<0.001 vs ANG1-7, ***P<0.001 vs baseline BL= Baseline; DRUG= drug-infusion; WO= wash-out (15 min after DRUG); REC1= recovery 1 (45 min after DRUG); REC2= recovery 2 (75 min after DRUG).