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. 2018 Sep 5;2018(9):CD012590. doi: 10.1002/14651858.CD012590.pub2

Comparison 1. Fluoroquinolones versus β‐lactam (amoxicillin).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Response rate ‐ treatment failure 2 83 Odds Ratio (M‐H, Fixed, 95% CI) 0.07 [0.01, 0.32]
1.1 Ciprofloxacin 1 42 Odds Ratio (M‐H, Fixed, 95% CI) 0.06 [0.01, 0.49]
1.2 Ofloxacin 1 41 Odds Ratio (M‐H, Fixed, 95% CI) 0.09 [0.01, 0.77]
2 Response rate ‐ microbiological response: patients with organisms eliminated 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
3 Response rate ‐ improvement in sputum purulence (excellent) 2 83 Odds Ratio (M‐H, Fixed, 95% CI) 2.35 [0.96, 5.72]
3.1 Ciprofloxacin vs amoxicillin 1 42 Odds Ratio (M‐H, Fixed, 95% CI) 1.5 [0.43, 5.25]
3.2 Ofloxacin vs amoxicillin 1 41 Odds Ratio (M‐H, Fixed, 95% CI) 3.79 [1.03, 13.91]
4 Response rate ‐ improvement in sputum purulence (fair) 2 83 Odds Ratio (M‐H, Fixed, 95% CI) 2.30 [0.88, 6.00]
4.1 Ciprofloxacin vs amoxicillin 1 42 Odds Ratio (M‐H, Fixed, 95% CI) 4.68 [1.17, 18.69]
4.2 Ofloxacin vs amoxicillin 1 41 Odds Ratio (M‐H, Fixed, 95% CI) 1.07 [0.26, 4.44]
5 Response rate ‐ relapse of sputum purulence at 3‐month follow‐up 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
6 Sputum volume (change mL) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
7 FEV1 % predicted (change) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected