TABLE.

Available evidence for EKG changes with donepezil

Study	Study Characteristics			Donepezil Dose Intervention	EKG Findings
	Study Design	Patient Population	Potential Patient Risk Factors
Pourmad et al17 (2017)	Case report	84-year-old male	Old age, possible structural heart disease	35 mg (accidental ingestion)	QTc = 502 ms
Kitt et al7 (2015)	Case report	80-year-old female	Old age, female, atrial fibrillation, polypharmacy	5 mg increased to 10 mg for 2 wk	QTc = 490 ms TdP occurred despite dose reduction
Igeta et all11 (2014)	Prospective cohort	N = 18 (80% male) Mean age = 74 years old	Old age	5-10 mg daily for an average of 4 mo	Prolonged PR interval; no change in QTc interval
Shinozaki8 (2012)	Case report	80-year-old female	Old age, female, polypharmacy	5 mg daily	QTc = 470 ms
Tanaka et al10 (2009)	Case report	90-year-old male	Old age	5 mg increased to 10 mg for 3 d	QTc = 514 ms Atrioventricular block
Takaya et al9 (2009)	Case report	87-year-old female	Old age, female, possible structural heart disease, atrial fibrillation, bradycardia, polypharmacy	5 mg daily	QTc #1 = 461 ms QTc #2 (1 mo later) = 594 ms TdP occurred
	Case report	83-year-old female	Old age, female, structural heart disease, atrial fibrillation, electrolyte abnormality	5 mg daily	QTc = 645 ms TdP occurred

EKG = electrocardiogram; PR = P-R interval on an EKG; TdP = torsades de pointes.