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. 2019 May 13;14(5):e0211658. doi: 10.1371/journal.pone.0211658

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© 2019 Karna et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — Overexpression of PIN1 induces the expression of PTOV1, which suggest that PIN1 might be the upstream protein which regulates the expression of PTOV1. Both the gene cooperatively share MAPK pathway including the expression of ERK, C-Jun and the master regulator C-Myc as well as induces the expression of apoptosis and autophagy related genes. PTOV1 interacts with RACK1 which is involved for protein synthesis in cancer similarly knockdown of PIN1 also inhibits RACK1 and thus PIN1 might contribute to oncogenic signalling via PTOV1-RACK1 interaction.