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. 2019 May 1;15(5):e1007669. doi: 10.1371/journal.ppat.1007669

Fig 1. AS1842856 allows HIV-1 infection of human resting T cells.

Fig 1

(A) Experimental design. After 7 days of culture with AS1842856 (500nM) or vehicle only, PBT were infected with a pseudotyped HIV-1 retrovirus encoding GFP. 3 days later GFP fluorescence in the viable cells was analyzed by FACS. Untreated T cells activated during 3 days with anti-CD3/CD28 beads before infection were used as a positive control. (B) Results obtained with one representative donor are shown in the left panel and mean results, +/- SE, with cells from five different donors in the right panel. (C) PBT treated 7 days with AS1842856 (500nM) or vehicle only were infected with the HIV-1 strain NL4.3. After 3 days of infection, GAG expression was measured by FACS using a GAG-specific antibody (left panel). Mean results +/- SE with cells from 3 different donors are shown in the right panel.