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(A) ELISA revealed improved antigen binding with VH clone 1 and VL clone 16, as well as the combination clone with both variable domains. (B) Fab fragments of C1, C16, and C1-16 showed improved KD values for muCCL20 when compared with parental AB1. (C) A cell-based β-arrestin assay demonstrated that the affinity-matured variants led to improved CCR6 receptor blocking activity when compared with the parental AB1 clone.
