Table 11. Integration of pharmacokinetic and pharmacodynamic variables (PK/PD) using the Montecarlo simulation.
| Dose (mg/Kg) | MIC (μg/mL) | AUC0-24h/MIC (h ±SD) |
PTA |
|---|---|---|---|
| 10 | 0.06 | 2331±738 | 99.70 |
| 0.125 | 1119±354 | 99.09 | |
| 0.25 | 559±177 | 97.92 | |
| 1 | 139±44 | 67.57 | |
| 2 | 70±22 | 0.00 | |
| 4 | 35±11 | 0.00 | |
| 15 | 0.06 | 2805±563 | 99.94 |
| 0.125 | 1346±270 | 99.87 | |
| 0.25 | 673±135 | 99.68 | |
| 1 | 168±33 | 89.58 | |
| 2 | 84±17 | 0.00 | |
| 4 | 42±8 | 0.00 | |
| 20 | 0.06 | 8580±823 | 100.00 |
| 0.125 | 4118±395 | 100.00 | |
| 0.25 | 616±115 | 100.00 | |
| 1 | 514±49 | 100.00 | |
| 2 | 257±24 | 99.99 | |
| 4 | 128±12 | 68.30 |
MIC: Minimum Inhibitory Concentration; SD: Standard deviation; PTA: Probability of reaching the objective AUC0-24h/MIC >125.