Table 3.
Anti-inflammatory effects of medicinal herbs
| Compounds/extracts | Herbs | Targets or indicator | References |
|---|---|---|---|
| Magnolol | Magnolia offinicalis | STAT3, ICAM-1, Tyr705 and Ser727, cyclin D1, MCP-1, monocyte adhesion | Chen et al. (2006) |
| Emodin | Rhubarb | PPAR-γ, GM-CSF, MMP-9 | Zhou et al. (2008) |
| Astragaloside IV | Astragalus membranaceus | CD40L, CD40, CXCR4, SDF-1 | Qin et al. (2015) |
| Cryptotanshinone | Salvia miltiorrhiza | Monocyte adhesion, ICAM-1, VCAM-1 | Ang et al. (2011) |
| Cryptotanshinone | Salvia miltiorrhiza | LOX-1, MMP-9, ROS, NF-κB, monocyte adhesion, ICAM-1, VCAM-1 | Liu et al. (2015) |
| Ethanol extract of Prunella vulgaris | Prunella vulgaris | VCAM-1, ICAM-1, E-selectin, ROS, ERK, p38 MAPK | Park et al. (2013) |
| Salvianolic acid B | Salvia miltiorrhiza | JAK2 (Tyr 1007/1008), STAT1 (Tyr701 and Ser727), CXC chemokines’ IP-10, Mig, I-TAC, monocyte adhesion, PIAS1, SOCS1 | Chen et al. (2011) |
| Salvianolic acid B | Salvia miltiorrhiza | MMP-2, MMP-9, ERK1/2, JNK | Lin et al. (2007) |
| Salvianolic acid B | Salvia miltiorrhiza | Soluble P-selectin, NF-κB, ICAM-1, IL-1β, IL-6, IL-8 and MCP-1 | Xu et al. (2014) |
| Honokiol | Magnolia officinalis | PTX3, IκB, NF-κB subunits (p50 and p65), IL-6, IL-8, MCP-1 | Qiu et al. (2015) |
| Eleven compounds of Folium eriobotryae | Folium eriobotryae | 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA | Zhang et al. (2015) |
| Artesunate | Sweet wormwood | TNF-α, IL-6, IL-8, MCP-1 | Jiang et al. (2016) |
| β-Elemene | Curcuma wenyujin | IL-1β, TNF-α, INF-γ, MCP-1, ICAM-1, NO, eNOS, Akt | Liu et al. (2017) |
| Plectranthus zeylanicus extract | Plectranthus zeylanicus | 5-LO | Napagoda et al. (2014) |
| Ethanol extract of Ziziphus nummularia | Ziziphus nummularia | MMP-2, MMP-9, NF-κB, ICAM-1, VCAM-1, adhesion of THP-1 monocytes | Fardoun et al. (2017) |
| Celastrus orbiculatus extract | Celastrus orbiculatus | CRP, IL-6, TNF-α, CD68, NF-κB p65 | Zhang et al. (2013) |
| Celastrol | Tripterygium wilfordii | IκB, iNOS, NO, TNF-α, IL-6 | Gu et al. (2013) |
| Bisacurone | Curcuma longa | VCAM-1, NF-κB p65, IκB, Akt, PKC, monocyte adhesion | Sun et al. (2008) |
| Patchouli alcohol | Pogpstemonis herba | MCP-1, iNOS, IL1β, IL-6, CXCL9, CXCL11 | Wang et al. (2016) |
| Tetrahdroxystilbene glucoside | Polygonum multiflorum | Calreticulin, vimentin, HSP70, lipocortin 1, Apo A-1 | Yao et al. (2013) |
| Do In Seung Gi-Tang | Rheum undulatum, Prunus persica, Conyza canadensis, Cinnamomum cassia, and Glycytthiza uralensis | Body weight, liver weight, TC, LDL-C, lipoprotein-cholesterol, TG, glucose, ICAM-1, VCAM-1, E-selectin, FAS, AMPK, ACC | Park et al. (2016) |