Asilian 2015.

Methods	Design: parallel ‐ 2 arms Country: Iran Method of randomisation: children were divided into 2 groups in double‐blind manner. Each group had 16 haemangiomas. Group A was treated with 585 PDL and timolol maleate and Group B with 585 PDL plus lubricant gel as a placebo. Blinding: double‐blind Location: Alzahra hospital (Referral Center for Treatment of Skin Diseases) Length of follow‐up: 6 months
Participants	Diagnosis: cutaneous haemangioma causing complications such as deformity, ulceration, bleeding, infection, or damage of orifices Sex: 24 female, 8 male Age: between 1 and 12 months Inclusion criteria: healthy infants between 1 month and 12 months old with superficial haemangioma ≤ 3 cm and with a history of sensitivity to beta blockers or asthma, renal disease, heart disease, hypoglycaemia, use of drugs that interact with beta blockers Exclusion criteria: haemangiomas > 3 cm, infants older than 1 year, no sensitivity to beta blockers Number of randomised children: 30 (2 children with 2 haemangiomas)
Interventions	Intervention A (Number of children: 15): children were treated with 4 sessions of PDL and timolol maleate gel 0.05%. Intervention B (Number of children: 15): PDL plus lubricant gel as placebo
Outcomes	Primary: improvement in appearance, colour, and size. 2 forms of assessment were used: (1) clinical score for the overall change and (2) visual analogue scale similar to that employed in other objective studies. Secondary: not stated
Notes	Trial registration: not stated Funder: not stated Role of funder: not stated A priori sample size estimation: not stated Conducted: January 2011 to January 2012 Declared conflicts of interest: not declared
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "Then, patients were divided into two groups in [a] double blind manner." Comment: There was insufficient information to rate this item as low or high risk of bias.
Allocation concealment (selection bias)	Unclear risk	There was insufficient information to rate this item as low or high risk of bias.
Blinding of participants (Performance bias)	Low risk	Quote: " (...) Group B with 585 PDL plus lubricant gel as placebo." Page 2 Comment: Placebo intervention was used.
Blinding of personnel (performance bias)	Unclear risk	There was insufficient information to rate this item as low or high risk of bias.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	There was insufficient information to rate this item as low or high risk of bias.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No children were lost at follow‐up.
Selective reporting (reporting bias)	Low risk	Selective reporting of information was not detected.
Other bias	Low risk	No other biases were detected.