Zhang 2013.

Methods	Design: parallel, 2 arms Country: China Method of randomisation: unclear Blinding: not stated Location: Ninth People's Hospital Length of follow‐up: unclear
Participants	Diagnosis: infantile haemangiomas Sex: male: 6; female: 6 Age: 2 to 12 months Inclusion criteria: written informed consent Exclusion criteria: not stated Number of randomised children: 12
Interventions	Intervention A (number of children: 6): oral propranolol 1 mg/kg/day, full dose once a day Intervention B (number of children: 6): oral propranolol 1 mg/kg/day, dose halved and given twice a day
Outcomes	Outcome A: plasma PRN concentrations at 2, 6, 10, and 24 hours
Notes	Trial registration: not stated Funder: not stated Role of funder: not stated A priori sample size estimation: not stated Conducted: not stated Declared conflicts of interest: yes (page 345)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: “12 patients were randomly divided into 2 groups, qd (n=6) and bid (n=6)...” Page 343 Comment: There was insufficient information to assess this item as low or high.
Allocation concealment (selection bias)	Unclear risk	There was insufficient information to assess this item as low or high.
Blinding of participants (Performance bias)	Unclear risk	There was insufficient information to assess this item as low or high.
Blinding of personnel (performance bias)	Unclear risk	There was insufficient information to assess this item as low or high.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	There was insufficient information to assess this item as low or high.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No children were lost at follow‐up.
Selective reporting (reporting bias)	High risk	Patient‐important outcomes were not addressed in this study.
Other bias	Low risk	No other biases were identified.