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. 2018 Sep 10;2018(9):CD007287. doi: 10.1002/14651858.CD007287.pub4

3. Assessment of quality of non‐randomised, (un)controlled studies.

  N Clear definition of inclusion/exclusion criteria Representative of true population Baseline characteristics adequately described Interventions clearly described Concomitant/ concurrent immunomodulatory treatment Outcome measures clearly specified Outcome measures relevant Outcome measures clearly reported Adequate rationale for number of patients Adequate description of exclusion /withdrawal Adequate presentation of results
Antonilli 2016 10 yes unknown yes yes no yes yes yes no no yes
Berinstein 2012 6 no unknown yes yes unknown yes yes yes no no yes
Berinstein 2013 19 yesa unknown no yesa yes no yes no no no no
Brossart 2000 3 yes unknown no yes unknown yes yes yes no no no
Chianese‐Bullock 2008 9 yes no yes yes unknown yes yes yes no yes no
Dhodapkar 2012 6 no unknown no no unknown no yes no unknown no no
Diefenbach 2008 9 yes no yes yes no yes yes yes no yes yes
Dijkgraaf 2015 6 yes no yes yes yes yes yes yes no yes yes
Ehlen 2005 13 yes yes yes yes unknown yes yes yes no yes yes
Galanis 2010 21 yes unknown no yes no yes yes yes no yes yes
Goh 2013 63 yesa unknown no no no no yes no no no no
Gribben 2005 6 no no no yes unknown no yes no yes yes no
Gulley 2008 3 yes unknown no yes unknown yes yes yes no yes no
Imhof 2013 15 yesa unknown no yes no no yes no no no no
Kaumaya 2009 5 no no no yes no yes yes yes no no no
Kawano 2014 42 yes no yes yes yes yes yes yes no no yes
Kobayashi 2014 56 yes unknown yes yes no no yes no no yes no
Le 2012 2 yes no no yes no yes yes yes no no no
Leffers 2009a 20 yes unknown yes yes no yes yes yes yes yes yes
Letsch 2011 8 unknown unknown no yes unknown unknown unknown unknown unknown unknown unknown
Ma 2002 4 no unknown no no unknown no no no no no no
MacLean 1992 10 no unknown no yes yes yes yes yes no no yes
MacLean 1996 34 yes unknown no yes yes no yes no no yes no
Möbus 2003 44 yes yes yes yes yes no yes yes no no yes
Mohebtash 2011 14 yes unknown no yes no yes yes yes no no no
Morse 2011 8 yes no no yes unknown yes yes no no yes no
Nicholson 2004 26 yes unknown no yes unknown yes yes yes no yes yes
Nishikawa 2006 4 no unknown no no unknown yes yes yes no no no
Noujaim 2001 184 yes yes yes no unknown yes yes yes no no yes
O'Cearbhaill 2016 24 yes yes yes yes no no yes no no no no
Odunsi 2007 18 no no yes yes unknown no yes yes no unknown yes
Odunsi 2012 22 no yes yes yes no yes yes yes no no yes
Odunsi 2014 12 yes unknown no yes yes yes yes yes no no yes
Ohno 2009 6 no unknown no yes no yes yes yes no yes yes
Peethambaram 2009 4 yes unknown no yes no yes yes no no no no
Pfisterer 2006 36 yes unknown no yes unknown yes yes yes no yes yes
Rahma 2012 21 no unknown no yes yes yes no no yes yes no
Reinartz 2004 119 yes unknown no yes no yes yes yes no no yes
Sabbatini 2000 25 yes yes yes yes unknown no yes yes no yes yes
Sabbatini 2007 11 yes unknown yes yes unknown yes yes yes yes yes no
Sabbatini 2012 28 yes no yes yes no yes yes yes yes yes no
Sandmaier 1999 7 yes unknown no yes no no yes yes no yes yes
Schultes 1998 75 no unknown no yes unknown no yes yes no no yes
Ströhlein 2009 2 yes no no yes unknown yes yes yes no yes yes
Suzuki 2016 32 yes no yes yes no yes yes yes no yes yes
Takeoka 2017 2 yes unknown no yes no yes yes yes no yes yes
Takeuchi 2013 38 yes unknown no yes no no yes no no no no
Tsuda 2004 5 yes no no yes no yes yes no no yes no
van Zanten‐Przybysz 2002 5 yes no yes yes unknown yes yes yes no yes yes
Vermeij 2012 12 yes no yes yes yes yes yes yes yes yes no
Wagner 1993 58 no unknown no yes unknown no yes no no no no

aSpecified in clinical trial register, not in publication.