7. Definitions and results of anti‐idiotypic (Ab2) humoral responses in antigen‐specific monoclonal antibody studies.

Study	N	Dose	Target antigen	Analysed	Positive if:	% positive	Robust if:	% robust
Baumann 2011	45	C1: 10‐10‐10‐10 μg C2: 10‐20‐50‐100 g	EpCAM	no
Berek 2001	252	2 mg	CA‐125	yes	> 50 ng/mL	63%	> 100 ng/mL
Berek 2004	145	2 mg	CA‐125	yes			> 100 ng/mL	67%
Berek 2009	371	2 mg	CA‐125	no
Braly 2009	40	unknown	CA‐125	yes			> 100 ng/mL	94% vs 74%
Buzzonetti 2014	129	2 mg	CA‐125	no
Ehlen 2005	13	2 mg	CA‐125	yes	> 50 ng/mL	45%
Gordon 2004	20	2 mg	CA‐125	yes	> 50 ng/mL		> 100 ng/mL	79%
Heiss 2010	129	10‐20‐50‐150 μg	EpCAM	no
Ma 2002	4	unknown	CA‐125	no
Method 2002	102	2 mg	CA‐125	yes			> 100 ng/mL	13% vs 31% vs 67%
Möbus 2003	44	2 mg	CA‐125	yes			> 50 ng/mL	77%
Nicholson 2004	26	25 mg	MUC1	yes	unknown	100%
Noujaim 2001	184	2 mg	CA‐125	yes
Pfisterer 2006	36	2 mg	CA‐125	no
Reinartz 2004	119	2 mg	CA‐125	no
Sabbatini 2006	42	2 mg/0.2 mg	CA‐125	no
Sabbatini 2013	888	2 mg	CA‐125	no
Schultes 1998	75	2 mg	CA‐125	yes	> 50 ng/mL	64%	> 250 ng/mL
Ströhlein 2009	2	10/20/40 μg 10/40/80 μg	EpCAM Her‐2/Neu	no
van Zanten‐Przybysz 2002	5	50 mg	membrane folate receptor	no
Wagner 1993	58	1 mg	CA‐125	yes	> 0 μ/L	64%	> 10 μ/L	32%