12. Definitions and results of human‐anti‐mouse antibody (HAMA) evaluation in antigen‐specific antibody studies.

Study	N	Dose	Target antigen	Analysed	Positive if:	% positive	Robust if:	% robust
Baumann 2011	45	C1: 10‐10‐10‐10 μg C2: 10‐20‐50‐100 μg	EpCAM	yes	unknown	C1: 61%, C2: 100%
Berek 2001	252	2 mg	CA‐125	yes			> 5000 ng/mL	51%
Berek 2004	145	2 mg	CA‐125	yes	> 200 ng/mL	unknown	> 5000 ng/mL	59%
Berek 2009	371	2 mg	CA‐125	yes	unknown	n.r.
Braly 2009	40	unknown	CA‐125	yes	unknown	SIM vs OWD: 100% vs 80%	> 3000 ng/mL	SIM vs OWD: 88% vs 74%
Buzzonetti 2014	129	2 mg	CA‐125	yes; reported in Sabbatini 2013
Ehlen 2005	13	2 mg	CA‐125	yes	> 200 ng/mL	100%	> 5000 ng/mL	58%
Gordon 2004	20	2 mg	CA‐125	yes	> 200 ng/mL	unknown	> 5000 ng/mL	79%
Heiss 2010	129	10‐20‐50‐150 μg	EpCAM	yes	unknown	not reported
Ma 2002	4	unknown	CA‐125	no
Method 2002	102	2 mg	CA‐125	yes	> 200 ng/mL	unknown	unknown	4% vs 36% vs 39%
Möbus 2003	44	2 mg	CA‐125	yes			> 5000 ng/mL	68%
Nicholson 2004	26	25 mg	MUC1	no
Noujaim 2001	184	2 mg	CA‐125	no
Pfisterer 2006	36	2 mg	CA‐125	yes	> 15 ng/mL	L vs S: 94% vs 100%
Reinartz 2004	119	2 mg	CA‐125	yes	> 100 ng/mL	78%
Sabbatini 2006	42	2 mg/0.2 mg	CA‐125	yes	> 100 ng/mL	90%
Sabbatini 2013	888	2 mg	CA‐125	yes	unknown	inadequately reported
Schultes 1998	75	2 mg	CA‐125	yes	> 200 ng/mL	90%
Ströhlein 2009	2	10/20/40 μg 10/40/80 μg	EpCAM Her2/Neu	yes	unknown	100% (n = 1)
van Zanten‐Przybysz 2002	5	50 mg	membrane folate receptor	n.a.
Wagner 1993	58	1 mg	CA‐125	no

n.r.: not reported.