Leffers 2009a.

Methods	Uncontrolled phase II study
Participants	20 women with epithelial ovarian cancer with (biochemical) recurrence not (yet) eligible for renewed chemotherapy
Interventions	Subcutaneous synthetic long peptides (p53) Adjuvant: Montanide ISA51
Outcomes	Survival (disease‐specific survival) Tumour responses Immune responses: humoral, cellular Adverse events
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Uncontrolled trial
Allocation concealment (selection bias)	High risk	Uncontrolled trial
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	IInformation insufficient to permit judgement of ‘low risk’ or ‘high risk’
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Information insufficient to permit judgement of ‘low risk’ or ‘high risk’
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Information insufficient to permit judgement of ‘low risk’ or ‘high risk’
Selective reporting (reporting bias)	Unclear risk	Information insufficient to permit judgement of ‘low risk’ or ‘high risk’
Other bias	Unclear risk	Information insufficient to permit judgement of ‘low risk’ or ‘high risk’