Morse 2011.
Methods | Uncontrolled phase I study | |
Participants | 15 ovarian and breast cancer patients with no evidence of disease after prior therapy (ovarian cancer n = 8) | |
Interventions | Intradermal and subcutaneous short peptides in 2 groups (group 1: APC, HHR6A, BAP31, replication protein A, Abl‐binding protein 3c, cyclin I; group 2: topoisomerase IIα/β, integrin β 8 subunit precursor, CDC2, TACE, g‐catenin, EEDDR1) Adjuvant: Montanide ISA‐51, GM‐CSF |
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Outcomes | Survival Immune responses: cellular Adverse events |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | Uncontrolled trial |
Allocation concealment (selection bias) | High risk | Uncontrolled trial |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Information insufficient to permit judgement of ‘low risk’ or ‘high risk’ |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Information insufficient to permit judgement of ‘low risk’ or ‘high risk’ |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Information insufficient to permit judgement of ‘low risk’ or ‘high risk’ |
Selective reporting (reporting bias) | Unclear risk | Information insufficient to permit judgement of ‘low risk’ or ‘high risk’ |
Other bias | Unclear risk | Information insufficient to permit judgement of ‘low risk’ or ‘high risk’ |