Comparison 2. TIVA vs inhalational maintenance: subgroup analysis (induction agents; and TCI vs non‐TCI).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Postoperative delirium (induction agents; and TCI vs non‐TCI)	5	321	Odds Ratio (M‐H, Random, 95% CI)	0.59 [0.15, 2.26]
1.1 Induction with inhalational agents, and TCI	1	50	Odds Ratio (M‐H, Random, 95% CI)	3.12 [0.12, 80.39]
1.2 Induction with intravenous agents, and non‐TCI	4	271	Odds Ratio (M‐H, Random, 95% CI)	0.42 [0.11, 1.67]
2 Postoperative cognitive dysfunction (induction agents)	7	869	Odds Ratio (M‐H, Random, 95% CI)	0.52 [0.31, 0.87]
2.1 Induction with inhalational agents	2	230	Odds Ratio (M‐H, Random, 95% CI)	0.87 [0.50, 1.50]
2.2 Induction with intravenous agents	5	639	Odds Ratio (M‐H, Random, 95% CI)	0.38 [0.20, 0.75]
3 Mortality (induction agents; and TCI vs non‐TCI)	3	271	Odds Ratio (M‐H, Random, 95% CI)	1.21 [0.33, 4.45]
3.1 Induction with inhalational agents, and TCI	1	28	Odds Ratio (M‐H, Random, 95% CI)	3.22 [0.12, 86.09]
3.2 Induction with intravenous agents, and non‐TCI	2	243	Odds Ratio (M‐H, Random, 95% CI)	1.01 [0.25, 4.16]
4 Intraoperative hypotension (induction agents)	11		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
4.1 Induction with inhalational agents	5		Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.2 Induction with intravenous agents	6		Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
5 Postoperative cognitive dysfunction (TCI vs non‐TCI)	7	869	Odds Ratio (M‐H, Random, 95% CI)	0.52 [0.31, 0.87]
5.1 TCI	2	294	Odds Ratio (M‐H, Random, 95% CI)	0.31 [0.07, 1.38]
5.2 non‐TCI	5	575	Odds Ratio (M‐H, Random, 95% CI)	0.63 [0.36, 1.10]
6 Intraoperative hypotension (TCI vs non‐TCI)	11		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
6.1 TCI	4		Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
6.2 non‐TCI	7		Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
7 Length of stay in the PACU (TCI vs non‐TCI)	7		Mean Difference (IV, Random, 95% CI)	Totals not selected
7.1 TCI	2		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
7.2 non‐TCI	5		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]