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. 2018 Aug 21;2018(8):CD012317. doi: 10.1002/14651858.CD012317.pub2

Comparison 2. TIVA vs inhalational maintenance: subgroup analysis (induction agents; and TCI vs non‐TCI).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Postoperative delirium (induction agents; and TCI vs non‐TCI) 5 321 Odds Ratio (M‐H, Random, 95% CI) 0.59 [0.15, 2.26]
1.1 Induction with inhalational agents, and TCI 1 50 Odds Ratio (M‐H, Random, 95% CI) 3.12 [0.12, 80.39]
1.2 Induction with intravenous agents, and non‐TCI 4 271 Odds Ratio (M‐H, Random, 95% CI) 0.42 [0.11, 1.67]
2 Postoperative cognitive dysfunction (induction agents) 7 869 Odds Ratio (M‐H, Random, 95% CI) 0.52 [0.31, 0.87]
2.1 Induction with inhalational agents 2 230 Odds Ratio (M‐H, Random, 95% CI) 0.87 [0.50, 1.50]
2.2 Induction with intravenous agents 5 639 Odds Ratio (M‐H, Random, 95% CI) 0.38 [0.20, 0.75]
3 Mortality (induction agents; and TCI vs non‐TCI) 3 271 Odds Ratio (M‐H, Random, 95% CI) 1.21 [0.33, 4.45]
3.1 Induction with inhalational agents, and TCI 1 28 Odds Ratio (M‐H, Random, 95% CI) 3.22 [0.12, 86.09]
3.2 Induction with intravenous agents, and non‐TCI 2 243 Odds Ratio (M‐H, Random, 95% CI) 1.01 [0.25, 4.16]
4 Intraoperative hypotension (induction agents) 11   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
4.1 Induction with inhalational agents 5   Odds Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
4.2 Induction with intravenous agents 6   Odds Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
5 Postoperative cognitive dysfunction (TCI vs non‐TCI) 7 869 Odds Ratio (M‐H, Random, 95% CI) 0.52 [0.31, 0.87]
5.1 TCI 2 294 Odds Ratio (M‐H, Random, 95% CI) 0.31 [0.07, 1.38]
5.2 non‐TCI 5 575 Odds Ratio (M‐H, Random, 95% CI) 0.63 [0.36, 1.10]
6 Intraoperative hypotension (TCI vs non‐TCI) 11   Odds Ratio (M‐H, Random, 95% CI) Totals not selected
6.1 TCI 4   Odds Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
6.2 non‐TCI 7   Odds Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
7 Length of stay in the PACU (TCI vs non‐TCI) 7   Mean Difference (IV, Random, 95% CI) Totals not selected
7.1 TCI 2   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
7.2 non‐TCI 5   Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]