Moffat 1995.

Methods	RCT, parallel design, single‐centre
Participants	Total number of randomized participants: 40 Inclusion criteria ASA I to III, > 60 years of age, undergoing cataract extraction and lens implantation under GA Exclusion criteria Not reported Type of surgery: cataract extraction and lens implantation Baseline characteristics TIVA group Age, mean (range): 72 (60 to 86) years Gender: not reported ASA grade: not reported Inhalational maintenance group Age, mean (range): 77 (64 to 88) years Gender: not reported ASA grade: not reported Country: Scotland, UK Setting: hospital
Interventions	TIVA group Participants: n = 20; 0 losses Induction details: premedication with metoclopramide 10 mg 1 hour before surgery. Topical anaesthesia (1% amethocaine) applied to non‐operative eye. Propofol with initial plasma concentration of 6 µg/mL reducing to 4 µg/mL after 10 minutes. Mix of 70% N2O in O2 throughout the procedure Maintenance details: 4 µg/mL propofol TCI Other information: topical anaesthesia with 1% amethocaine in operative eye before surgical incision. Airway maintained with LMA Inhalational maintenance group Participants: n = 20; 0 losses Induction details: premedication with metoclopramide 10 mg 1 hour before surgery. Topical anaesthesia (1% amethocaine) applied to non‐operative eye. Induction with etomidate 0.25 mg/kg and vecuronium 0.075 mg/kg. Maintenance details: Mix of 70% N2O in oxygen, and 0.5% to 1% isoflurane Other information: topical anaesthesia with 1% amethocaine in operative eye before surgical incision. Airway maintained with intubation
Outcomes	Haemodynamic measures Recovery times from anaesthesia PONV Ability to converse normally, walk unaided and retain oral fluids Cognitive function assessed using MMSE
Notes	Funding/declarations of interest: not reported Study dates: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Participants were randomly allocated to groups; no additional details
Allocation concealment (selection bias)	Unclear risk	No details
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not feasible to blind anaesthetists to intervention groups
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details
Incomplete outcome data (attrition bias) All outcomes	Low risk	No apparent loss of study participants
Selective reporting (reporting bias)	Unclear risk	Study authors do not report clinical trials registration. Not feasible to judge risk of selective outcome reporting
Other bias	Unclear risk	We noted use of different types of airway management which was because of the study aim to assess anaesthetic management using neuromuscular blockade vs no neuromuscular blockade for intraocular pressure