Moffat 1995.
Methods | RCT, parallel design, single‐centre | |
Participants |
Total number of randomized participants: 40 Inclusion criteria
Exclusion criteria
Type of surgery: cataract extraction and lens implantation Baseline characteristics TIVA group
Inhalational maintenance group
Country: Scotland, UK Setting: hospital |
|
Interventions |
TIVA group Participants: n = 20; 0 losses Induction details: premedication with metoclopramide 10 mg 1 hour before surgery. Topical anaesthesia (1% amethocaine) applied to non‐operative eye. Propofol with initial plasma concentration of 6 µg/mL reducing to 4 µg/mL after 10 minutes. Mix of 70% N2O in O2 throughout the procedure Maintenance details: 4 µg/mL propofol TCI Other information: topical anaesthesia with 1% amethocaine in operative eye before surgical incision. Airway maintained with LMA Inhalational maintenance group Participants: n = 20; 0 losses Induction details: premedication with metoclopramide 10 mg 1 hour before surgery. Topical anaesthesia (1% amethocaine) applied to non‐operative eye. Induction with etomidate 0.25 mg/kg and vecuronium 0.075 mg/kg. Maintenance details: Mix of 70% N2O in oxygen, and 0.5% to 1% isoflurane Other information: topical anaesthesia with 1% amethocaine in operative eye before surgical incision. Airway maintained with intubation |
|
Outcomes |
|
|
Notes |
Funding/declarations of interest: not reported Study dates: not reported |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Participants were randomly allocated to groups; no additional details |
Allocation concealment (selection bias) | Unclear risk | No details |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Not feasible to blind anaesthetists to intervention groups |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | No details |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No apparent loss of study participants |
Selective reporting (reporting bias) | Unclear risk | Study authors do not report clinical trials registration. Not feasible to judge risk of selective outcome reporting |
Other bias | Unclear risk | We noted use of different types of airway management which was because of the study aim to assess anaesthetic management using neuromuscular blockade vs no neuromuscular blockade for intraocular pressure |