Rohan 2005.
Methods | RCT, parallel design, single‐centre | |
Participants |
Total number of randomized participants: 30 Inclusion criteria:
Exclusion criteria
Type of surgery: minor urological or gynaecological surgery Baseline characteristics TIVA group
Inhalational maintenance group
Country: Ireland Setting: hospital |
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Interventions |
TIVA group Participants: n = 15; 0 losses Induction details: 500 mL crystalloid solution, fentanyl 1 µg/kg IV, propofol TCI using a Deprifusor Maintenance details: TCI propofol adjusted to maintain adequate depth of anaesthesia, at discretion of attending anaesthetist. 50% O2 and 50% air Inhalational maintenance group Participants: n = 15; 0 losses Induction details: 500 mL crystalloid solution, fentanyl 1 µg/kg IV. Incremental dose of sevoflurane by tidal volume inhalation induction technique Maintenance details: 50% O2 and 50% air. No additional information for maintenance |
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Outcomes |
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Notes |
Funding/declarations of interest: funded entirely from the resources of the Department of Anesthesia, Critical Care and Pain Medicine, Mater Misericordiae Hospital Study dates: not reported Note: study also includes an age‐matched control group of participants which we did not include in the review |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Participants were randomized to groups; no additional details |
Allocation concealment (selection bias) | Low risk | Use of sequentially numbered sealed envelopes |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Not feasible to blind anaesthetists to intervention groups |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Quote: "the investigator who undertook patient enrolment, neuropsychological tests and blood tests did not deliver anaesthesia to the patient and, therefore, was unaware of study group allocation." |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No apparent loss of study participants |
Selective reporting (reporting bias) | Unclear risk | Study authors do not report clinical trials registration. Not feasible to assess risk of selective outcome reporting |
Other bias | Unclear risk | No detail on doses of anaesthetic drugs. Unable to assess whether groups were equivalent |