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. 2018 Aug 21;2018(8):CD012317. doi: 10.1002/14651858.CD012317.pub2

Tan 2009.

Methods RCT, parallel design, single‐centre
Participants Total number of randomized participants: 60
Inclusion criteria
  1. Undergoing abdominal surgery, > 60 years of age, ASA I to II


Exclusion criteria
  1. Neurological abnormalities

  2. Regularly taking medication for neuropsychiatric disorders


Type of surgery: abdominal surgery
Baseline characteristics
TIVA group
  1. Age, range: 60 to 81 years

  2. Gender: not reported

  3. ASA grade: not reported


Inhalational maintenance group
  1. Age, range: 60 to 81 years

  2. Gender: not reported

  3. ASA grade: not reported


Note: Study authors do not report a baseline characteristics table. Study authors report no differences between group in age, weight, height and general condition
Country: China
Setting: hospital
Interventions TIVA group
Participants: n = 30; 0 losses
Induction details: propofol IV 1.5 mg/kg to 2 mg/kg, fentanyl 2 µg/kg to 4 µg/kg, vecuronium 0.1 mg/kg
Maintenance details: propofol IV 100 µg/kg/min to 150 µg/kg/min, fentanyl and vecuronium as required
Inhalational maintenance group
Participants: n = 30; 0 losses
Induction details: propofol IV 1.5 mg/kg to 2 mg/kg, fentanyl 2 µg/kg to 4 µg/kg, vecuronium 0.1 mg/kg
Maintenance details: 1% to 2 % isoflurane, fentanyl and vecuronium as required
Outcomes
  1. POCD, using MMSE before and after surgery (1, 6, 12, 24 and 48 hours after surgery)

  2. Intraoperative stress response

  3. HR

  4. MAP

  5. BIS

Notes Funding/declarations of interest: not reported
Study dates: not reported
Note: study report is in Chinese. We have used Google translate for essential paragraphs. We noted that this study was reported by a single author and may not be the original study report; we checked the study details against other included studies for duplication but found no duplication
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Participants were randomized to groups; no additional details
Allocation concealment (selection bias) Unclear risk No details
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not feasible to blind anaesthetists to intervention groups
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk No details
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No apparent loss of study participants
Selective reporting (reporting bias) Unclear risk Study authors do not report clinical trials registration. Not feasible to judge risk of selective outcome reporting
Other bias Unclear risk No baseline characteristics table. Limited information in short report, and we noted that this study was reported by a single author