Trembach 2012.

Methods	RCT, parallel design, single‐centre
Participants	Total number or randomized participants: 99 Included criteria ASA III patients with acute cholecystitis undergoing laparoscopic cholecystectomy Excluded criteria Not reported (abstract only) Type of surgery: laparoscopic cholecystectomy Baseline characteristics not reported (abstract only) Country: not reported Setting: hospital
Interventions	TIVA group Participants: n = 45; 0 reported losses Described as propofol‐fentanyl TIVA. No additional details in abstract Inhalational maintenance group Participants: n = 44; 0 reported losses Described a VIMA. No additional details in abstract
Outcomes	Hypotension (requiring support with phenylephrine) Induction time Time to intubation Time to recovery of consciousness Time to extubation Time to full orientation PONV Participant satisfaction Cost Cardiovascular events
Notes	Funding/declarations of interest: not reported Study dates: not reported Very limited detail in abstract
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Participants were randomly assigned to groups; no additional details
Allocation concealment (selection bias)	Unclear risk	No details. Abstract only
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not feasible to blind anaesthetists to intervention
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details. Abstract only
Incomplete outcome data (attrition bias) All outcomes	Low risk	No details. Abstract only. We have assumed there were no losses
Selective reporting (reporting bias)	Unclear risk	Study authors do not report clinical trials registration. Not feasible to judge risk of selective outcome reporting
Other bias	Unclear risk	Limited detail in abstract, unable to assess risk of other biases. Description of inhalational maintenance does not include fentanyl/remifentanil