| Study | Reason for exclusion |
|---|---|
| Arar 2005 | RCT, measuring effects of sevoflurane versus isoflurane versus propofol infusions on postoperative recovery criteria in geriatric participants. Outcomes measured: time to spontaneous eye opening, extubation, response to verbal stimuli, and orientation. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Arnaoutoglou 2007 | RCT, measuring effects of propofol versus sevoflurane on the production of free oxygen radicals during total knee arthroplasty in elderly participants. Outcomes measured: MDA levels. Post‐hoc decision to exclude studies that did not measure review outcomes |
| But 2003 | Unclear if this is an RCT. Measures effects of sevoflurane versus propofol on hepatic and renal functions in participants > 65 years of age. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Carles 2008 | RCT, measuring effects of sevoflurane versus propofol versus spinal anaesthesia on levels of interstitial glycolysis metabolites in elderly participants. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Doe 2016 | RCT, measuring effects of sevoflurane versus propofol on jugular venous bulb oxygenation (SjO2) and regional oxygen saturation in participants undergoing robotic‐assisted laparoscopic prostatectomy. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Filipovic 2007 | RCT, measuring effects of anaesthetics on left ventricular diastolic function in participants aged between 18 and 75. Outcomes measured: haemodynamic parameters. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Fredman 2002 | RCT, measuring the effects of propofol verses sevoflurane on postanaesthesia recovery in geriatric participants. Outcomes measured: emergence time, time to orientation, postanaesthesia recovery scores, and therapeutic interventions. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Gasowska 1999 | RCT, measuring effects of halothane versus isoflurane versus propofol on venous admixture in participants between 28 to 72 years of age. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Gauger 2008 | RCT, measuring effects of propofol on postoperative nausea and vomiting in participants undergoing thyroid and parathyroid operations. Outcomes measured: occurrences of nausea and vomiting. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Guedes 1988 | RCT, measuring effects of propofol versus enflurane on intraocular pressure in elderly participants. Outcomes measured: haemodynamic parameters. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Halberg 1996 | Unclear if this is an RCT. A pharmaco‐economic evaluation of anaesthesia in ambulatory surgery comparing desflurane verses isoflurane and propofol. Unable to source full text. Post‐hoc decision to exclude studies that did not measure review outcomes. Decision made from information in the abstract |
| Holst 1993 | Unclear if this is an RCT. A comparison of the intraoperative sympatho‐adrenergic response and the postoperative vigilance of a propofol/alfentanil anaesthesia to a conventional isoflurane anaesthesia. Unable to source full text. Post‐hoc decision to exclude studies that did not measure review outcomes. Decision made from information in the abstract |
| Hosseinzadeh 2013 | RCT, measuring effects of propofol versus isoflurane on incidence of postoperative nausea and vomiting in participants between 16 to 65 year of age. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Ionescu 2009 | Unclear if this is an RCT. Effects of TIVA versus isoflurane on postoperative nausea and vomiting, and patient satisfaction, in participants undergoing laparoscopic cholecystectomy. Unable to source full text. Post‐hoc decision to exclude studies that did not measure review outcomes. Decision made from information in the abstract |
| Ito 2012 | RCT, measuring effects of TIVA versus desflurane on postoperative emergence in elderly participants. Outcomes measured: presence of spontaneous speech, early recovery time, time to extubation, eye opening, and squeezing fingers on command. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Kadoi 2009a | RCT, measuring effects of propofol versus sevoflurane on cerebrovascular carbon dioxide reactivity in elderly participants. Outcomes measured: cerebral circulation. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Kim 2015b | RCT, measuring effects of propofol versus desflurane on postoperative spirometry in elderly after knee surgery. Outcomes measured: spirometry parameters. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Konstantopoulos 2013a | RCT, measuring effects of sevoflurane versus propofol on recovery characteristics in older participants. Outcomes measured: haemodynamic stability, recovery characteristics, postoperative nausea and vomiting, and pain intensity. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Kvarnstrom 2012 | RCT, measuring effects of sevoflurane versus propofol on complement activation and the release of inflammatory interleukins in participants undergoing major abdominal surgery. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Malcharek 2015 | RCT, measuring effects of desflurane versus propofol on tcMEP amplitudes in participants without PMDs undergoing CEA. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Manolescu 2012 | Unclear if this is an RCT. Evaluation of cardioprotective effects of sevoflurane versus propofol in patients with cardiac risk, undergoing noncardiac surgery. Unable to source full text. Post‐hoc decision to exclude studies that did not measure review outcomes. Decision made from information in the abstract |
| Mets 1992 | RCT, measuring effects of propofol versus isoflurane in elderly participants undergoing ophthalmic surgery. Outcomes measured: haemodynamic parameters. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Murray 1994 | RCT, measuring effects of isoflurane versus propofol on hepatic glutathione‐S‐transferase concentrations. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Mutch 1995 | RCT, measuring effects of propofol versus isoflurane in older patients undergoing carotid endarterectomy. Outcomes measured: haemodynamic parameters. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Ohe 2014 | Unclear if this is an RCT. Compares effects of sevoflurane versus propofol on preventing intraoperative hypothermia. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Oikkonen 1992 | RCT, measuring effects of isoflurane versus alfentanil‐methohexitone verses propofol on arterial pressure or heart rate in geriatric participants. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Passot 2005 | RCT, measuring effects of target‐ versus manually‐controlled infusion of propofol and desflurane in elderly participants undergoing hip fracture surgery. Outcomes measured: haemodynamic parameters. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Pirttikangas 1996 | RCT, measuring effects of propofol versus combined isoflurane in elderly participants undergoing ophthalmic surgery. Outcomes measured: immune responses. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Polarz 1995 | RCT, measuring effects of isoflurane versus propofol on participants undergoing ophthalmic surgery. Outcomes measured: intraocular pressure. Unable to source full text. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Sal'nikov 2003 | Unclear if this is an RCT. A comparative evaluation of "cerebral oximetry" during anaesthesia with xenon and other anaesthetics. Unable to source full text. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Schilling 2007 | RCT, measuring effects of propofol versus desflurane in older participants undergoing open thoracic surgery. Outcomes measured: alveolar inflammatory response to one‐lung ventilation. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Schilling 2011 | RCT, measuring effects of propofol versus desflurane versus sevoflurane in older participants undergoing open thoracic surgery. Outcomes measured: alveolar inflammatory response. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Schäfer 2002 | RCT, measuring effects of propofol versus sevoflurane in participants aged over 50 undergoing cataract surgery. Outcomes measured: intraocular pressure. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Shao 2013 | RCT, measuring effects of propofol versus sevoflurane in elderly participants. Outcomes measured: quality of neuromuscular blockade with cisatracurium. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Sohn 2008 | RCT, measuring effects of propofol versus sevoflurane in elderly participants undergoing total knee arthroplasty. Outcomes measured: haemodynamic parameters. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Sugata 2012 | RCT, measuring effects of propofol versus sevoflurane in participants undergoing prone spine surgery. Outcomes measured: intraocular pressure. Unable to source full text. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Trifu 2011 | RCT, measuring effects of propofol versus sevoflurane in participants aged between 16 and 76 undergoing elective neurosurgery. Unable to source full text. Outcomes measured: cardiovascular stability, recovery characteristics, and side effects. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Tufano 2000 | RCT, measuring effects of propofol versus sevoflurane in participants aged between 18 and 70. Outcomes measured: drug consumption, intraoperative responses, and times of recovery. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Ueda 1999 | RCT, measuring effects of sevoflurane versus propofol combined with thoracic epidural anaesthesia on arterial oxygenation during one‐lung ventilation for thoracotomy. Unable to source full text. Outcomes measured: haemodynamic parameters. Post‐hoc decision to exclude studies that did not measure review outcomes. Decision made from information in the abstract |
| Wakabayashi 2014 | RCT, measuring effects of sevoflurane versus propofol in older participants undergoing oesophagectomy. Outcomes measured: levels of cytokine and chemokine at the airway epithelium. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Weilbach 2005 | RCT, measuring effects of TIVA versus BA in elderly participants undergoing a cataract operation. Outcomes measured: patient satisfaction. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Wen 2010 | RCT, measuring effects of sevoflurane versus propofol on neuromuscular blockade produced by continuous cisatracurium infusion. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Wormald 2005 | RCT, measuring effects of sevoflurane versus propofol on the surgical field. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Yu 2010a | RCT, measuring effects of sevoflurane versus propofol in elderly patients undergoing abdominal surgery. Outcomes measured: haemodynamic parameters. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Zabolotskikh 2013 | Unclear if this is an RCT. Measuring effects of sevoflurane versus propofol on intracerebral and cerebral perfusion pressure. Post‐hoc decision to exclude studies that did not measure review outcomes |
| Zhang 2014 | RCT, measuring effects of propofol versus propofol and sevoflurane versus sevoflurane on immune responses in patients undergoing surgery for tongue cancer. Post‐hoc decision to exclude studies that did not measure review outcomes |
BA: balanced anaesthesia CEA: carotid endarterectomy MDA: malondialdehyde PMDs: pre‐existing motor deficits RCT: randomized control trial SjO2: jugular venous bulb oxygenation saturation tcMEP: transcranial electrical motor evoked potential TIVA: total intravenous anaesthesia