NCT02133638.

Trial name or title	Sevoflurane decreases the risk of postoperative delirium after cerebral hypoxemia during surgery
Methods	RCT, parallel design
Participants	Target number of randomized participants: 130 Inclusion criteria ASA III to IV, history of arterial vascular disease (arterial hypertension, myocardial ischaemia and/or cerebral vascular disease), undergoing elective non‐cardiac surgery (hemicolectomy, hernioplasty, laparoscopic cholecystectomy and laparoscopic hysterectomy), 65 to 80 years of age Exclusion criteria Dementia Stroke or myocardial infarction ≤ 6 months before surgery Oncological disease of T2‐4N3M1 stage Type of surgery: elective non‐cardiac surgery (hemicolectomy, hernioplasty, laparoscopic cholecystectomy and laparoscopic hysterectomy) Country: Russia Setting: hospital
Interventions	TIVA group Induction details: propofol 2 mg/kg and fentanyl 4 µg/kg Maintenance details: infusion of propofol 8 mg/kg/hour and boluses of fentanyl 3 µg/kg Inhalational maintenance group Induction details: fentanyl 2 µg/kg and a bolus inhalation of 8% sevoflurane in an 8 L/min fresh gas flow Maintenance details: 1 MAC sevoflurane at a low fresh gas flow of 0.6 to 0.8 L/min in a 60% air‐oxygen mixture supplemented with boluses of fentanyl
Outcomes	Regional cerebral oxygenation Peripheral tissue oxygen saturation Non‐invasive blood pressure Postoperative delirium (using CAM 24 and 48 hours postoperatively) Plasma concentration of S100b protein
Starting date	May 2014
Contact information	Yuri V Iljin, Negovsky Reanimatology Research Institute, Moscow, Russia
Notes