NCT02662257.
Trial name or title | Impact of anaesthesia maintenance methods on incidence of postoperative delirium |
Methods | RCT, parallel design |
Participants |
Target number of randomized participants: 1200 Inclusion criteria
Exclusion criteria:
Type of surgery: treatment of tumour Country: China Setting: hospital |
Interventions |
TIVA group Details: propofol adjusted to maintain BIS 40 to 60, with or without 50% nitrous oxide. Remifentanil (administered by continuous infusion), sufentanil (administered by intermittent injection/continuous infusion), or fentanyl (administered by intermittent injection). Towards the end of surgery, propofol infusion rate will be decreased and fentanyl/sufentanil will be administered when necessary Inhalational maintenance group Details: sevoflurane adjusted to maintain BIS 40 to 60, with or without 50% nitrous oxide. Remifentanil (administered by continuous infusion), sufentanil (administered by intermittent injection/continuous infusion), or fentanyl (administered by intermittent injection). Towards the end of surgery, sevoflurane inhalational concentration will be decreased and fentanyl/sufentanil will be administered when necessary |
Outcomes |
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Starting date | April 2015 |
Contact information | Dong‐Xin Wang, MD, PhD, Peking University FIrst Hospital |
Notes | Also registered as ChiCTR‐IPR‐15006209 |