NCT03194074.

Trial name or title	Early cognitive function in elderly patients after laser laryngeal surgery: des vs prop
Methods	RCT, parallel design
Participants	Target number of randomized participants: 70 Inclusion criteria Scheduled for laser laryngeal surgery under GA Exclusion criteria Cardiac, pulmonary, hepatic, or renal dysfunction Epilepsy Uncontrolled hypertension Taking medications that influence the central nervous system Showing obvious alteration of mental status Refusal to participate Type of surgery: laser laryngeal surgery Country: China Setting: hospital
Interventions	TIVA group Maintenance details: propofol at a rate 75 to 150 µg/kg/min and remifentanil at 0.1 to 0.3 µg/kg/min maintained throughout surgery Inhalational maintenance group Maintenance details: desflurane at end‐tidal concentration at 0.7 to 1.0 MAC and remifentanil 0.1 to 0.3 µg/kg/min
Outcomes	Change of MMSE (day before surgery and 30min postoperatively) MMSE scores at 1, 3, and 24 hours postoperatively
Starting date	15 August 2017
Contact information	Xia Shen, MD (zlsx@yahoo.com) or Hui Qiao, MD (theyellow@163.com)
Notes	Study does not specifically recruit elderly participants. Once completed, we would need to ascertain whether mean age of participants is > 60 years of age

ApoJ: Apolipoprotein J
 ARDS: acute respiratory distress syndrome
 ASA: American Society of Anesthesiologists
 BIS: Bispectral Index
 BMI: body mass index
 CAM: confusion assessment method
 CD: cluster of differentiation
 EORCT QLQ‐C30: (quality of life questionnaire for cancer patients)
 GA: general anaesthesia
 ICU: intensive care unit
 IL: interleukin
 MAC: minimum alveolar concentration
 MCI: mild cognitive impairment
 MI: myocardial infarction
 MMSE: Mini‐Mental State Examination
 MoCA: Montreal Cognitive Assessment
 PACU: postanaesthesia care unit
 POCD: postoperative cognitive dysfunction
 PONV: postoperative nausea and vomiting
 QOR‐40: quality of recovery questionnaire
 RCT: randomized control trial
 TGF: transforming growth factor
 TCI: target‐controlled infusion
 TICS‐m: Telephone Interview for Cognitive Status‐Modified
 TIVA: total intravenous anaesthesia
 TNF: tumour necrosis factor
 VEGF: vascular endothelial growth factor