| Study | Reason for exclusion |
|---|---|
| Casey 1979 | Allocation: not randomised, cohort study. |
| Casey 1980 | Allocation: not randomised. |
| Cassady 1992 | Allocation: randomised. Participants: people with TD. Intervention: muscimol versus placebo, unstable dose of antipsychotic drugs. Outcomes: only reported after 2 hours |
| Cassady 1993 | Allocation: not randomised, ABA study. |
| Chien 1978 | Allocation: randomised. Participants: people with TD. Intervention: sodium valproate versus oxypertine versus deanol. Outcomes: Unable to extract data from first cross‐over phase (TD improvement, AIMS, Leaving the study early). We were unable to identify up‐to‐date study author contact details for this over 35‐year old study. |
| Chiu 2006 | Allocation: randomised, cross‐over design. Participants: people with Schizophrenia. Interventions: ginseng versus placebo, not GABA agonist. |
| Danion 1984 | Allocation: not randomised. |
| Frangos 1980 | Allocation: randomised. Participants: people with TD. Intervention: baclofen versus placebo. Outcomes: not possible to extract data; published only as a conference proceeding ‐ authors contacted in 1996 and did not reply. |
| Friis 1983 | Allocation: randomised, cross‐over design. Participants: people with TD. Interventions: valproate versus biperiden versus placebo. Outcomes: no data from first period; Dr Gerlach contacted and replied promptly; data were destroyed and no more information is available. |
| Gibson 1978 | Allocation: not randomised, cohort study. |
| Gulmann 1976 | Allocation: randomised. Participants: people with schizophrenia, not TD. Interventions: baclofen versus placebo; 19/20 participants were given chlorpromazine. |
| Korsgaard 1976 | Allocation: randomised, cross‐over design. Participants: people with antipsychotic‐induced TD. Intervention: baclofen versus placebo. Outcomes: not possible to extract data from first period; authors contacted in 1996 and did not reply. The study was excluded as it is over 35 years old and further attempts to contact authors will likely not be fruitful. |
| Korsgaard 1982 | Allocation: not randomised. |
| Korsgaard 1983 | Allocation: not randomised. |
| Lambert 1982 | Allocation: not randomised. |
| Monteleone 1988 | Allocation: not randomised, case‐control study. |
| Morselli 1985 | Allocation: not randomised. |
| Nagao 1979 | Allocation: not randomised. |
| Nasrallah 1985 | Allocation: not randomised. |
| Nasrallah 1986 | Allocation: randomised. Participants: schizophrenia, paranoid disorder, and schizoaffective disorder + Schooler and Kane criteria for persistent TD. Interventions: AMPT vs L‐DOPA vs Choline chloride vs Valproic acid vs Hydroxytryptophan Outcomes: No outcome data have been provided for the first period before cross‐over. Study author was contacted for data; no additional information was received, so this 25‐year old study was excluded. |
| Nordic 1986 | Allocation: randomised, cross‐over design. Interventions:chlorprothixene, perphenazine, haloperidol and haloperidol + biperiden versus placebo, not GABA agonist. |
| Raptis 1990 | Allocation: randomised. Participants: people with schizophrenia without TD. |
| Rondot 1987 | Allocation: not randomised. |
| Sikich 1999 | Allocation: randomised, double‐blind. Participants: 8 to 19 year olds with active psychotic symptoms, not TD. Interventions: haloperidol, risperidone, and olanzapine, not GABA agonist. |
| Simpson 1978 | Allocation: not randomised. |
| Stahl 1985 | Allocation: not randomised. |
| Tamminga 1978 | Allocation: double‐blind methodology, randomisation not stated. Participants: people with schizophrenia without TD. |
| Tamminga 1979 | Allocation: randomised. Participants: people free from antipsychotic drugs for < 1 month: dose unstable. Intervention: muscimol versus placebo. Outcomes: no usable data. |
| Tamminga 1983 | Allocation: randomised, cross‐over design. Participants: people with TD. Intervention: GVG versus placebo. Outcomes: not possible to extract data from first period; authors contacted three times in 1996, did reply, but did not provide any further information. |
| Tell 1981 | Allocation: not randomised. |
TD ‐ tardive dyskinesia TD scales AIMS ‐ Abnormal Involuntary Movement Scale
GABA ‐ Gamma‐aminobutyric acid GABA compounds GVG ‐ Gamma‐vynil GABA GAG ‐ Gamma‐acetylenic GABA THIP ‐ Tetrahydroisoxazolopyridinol
Outcome SCD ‐ Saccadic distractibility