Polisca 1992.

Methods	Single‐centre, double‐blind, randomised, parallel study: fluoxetine versus placebo No control for symptomatic/analgesic medications use
Participants	Country: Italy N = 60 Sex: 22 M, 38 F Mean age: 43.5 (SD 2.1) fluoxetine; 39 (SD 0.8) placebo Diagnosis: transformed migraine (chronic daily migraine headache, according to Manzoni and Nappi (Nappi 1985), with a 6‐year or longer history) Exclusion criteria: unclear Recruitment: no information provided
Interventions	N = 30 fluoxetine 20 mg/day N = 30 placebo Active treatment: 12 weeks
Outcomes	1. Pain Total Index (not defined) 2. Migraine Index (not defined) 3. Frequency (number of headache days/30 days) 4. Symptomatic/analgesic drug consumption
Notes	No drop‐outs Article in Italian The report omits important details No sample size calculation
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information
Allocation concealment (selection bias)	Unclear risk	No information
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Neither doctors nor patients were able to foresee the assignment (not specified how)
Incomplete outcome data (attrition bias) All outcomes	Low risk	No drop‐outs
Selective reporting (reporting bias)	Unclear risk	No information
Other bias	Unclear risk	Financial support not reported