Dodd 2016.

Trial name or title	Metformin and dietary advice to improve insulin sensitivity and promote gestational restriction of weight among pregnant women who are overweight or obese: the GRoW Randomised Trial
Methods	Randomised controlled trial across 3 metropolitan hospitals in Adelaide, South Australia. Women were enrolled from 2013 until 2016
Participants	Included: women with BMI ≥ 25 kg/m2, singleton pregnancy, between 10 + 0 and 20 weeks of gestation, without type 1, 2 or gestational diabetes Excluded: women with a contraindication to taking metformin, congenital fetal anomaly or planning to birth at a hospital not involved with the study
Interventions	Intervention: women receive up to 2 g of metformin (titrated from 500 mg over 2 weeks) in divided doses morning and night, from trial entry until birth Control: women receive up to 4 tablets daily, identical in taste and appearance to the metformin tablets, (titrated from 1 tablet over 4 weeks), from trial entry until birth All women received a comprehensive dietary and lifestyle intervention across the duration of pregnancy.
Outcomes	Incidence of infants born with birthweight of 4 kg or more Maternal clinical outcomes Gestational weight gain Birth by caesarean Infection Antenatal admission and length of stay Perineal trauma Shoulder dystocia Postpartum haemorrhage Infant clinical outcomes Birthweight of 4.5 kg or more Large‐for‐gestational age Small‐for‐gestational age Admission to the nursery Hypoglycaemia Hyperbilirubinaemia Gestational age at birth Preterm birth Preterm prelabour rupture of the membranes Apgar score of less than 7 at 5 minutes Breastfeeding on hospital discharge
Starting date	May 2013
Contact information	Jodie Dodd (jodie.dodd@adelaide.edu.au)
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