Sensitivity analysis: comparison of risk ratio effect estimates for the composite outcome of 'any local reaction' in the Diggle 2006 trial at various time points Population: infants aged 2 to 4 months undergoing DTwP‐Hib vaccination Interventions: 25 G 25 mm vs 23 G 25 mm needles Outcomes: any local reaction (any swelling, redness, tenderness, or hardness)
Time points and vaccine dose	Risk ratio (95% CI)
6 hours after first dose	0.88 (0.76 to 1.02)
Day 1 after first dose	0.92 (0.73 to 1.17)
Day 2 after first dose	0.92 (0.62 to 1.38)
Day 3 after first dose	1.23 (0.66 to 2.29)
At any time point after first dose	0.90 (0.79 to 1.03)
6 hours after second dose	0.90 (0.76 to 1.08)
Day 1 after second dose	0.89 (0.70 to 1.12)
Day 2 after second dose	0.78 (0.56 to 1.10)
Day 3 after second dose	0.66 (0.38 to 1.14)
At any time point after second dose	0.92 (0.79 to 1.08)
6 hours after third dose	0.84 (0.70 to 1.02)
Day 1 after third dose	0.84 (0.66 to 1.06)
Day 2 after third dose	0.67 (0.47 to 0.95)
Day 3 after third dose	0.81 (0.46 to 1.43)
At any time point after third dose	0.79 (0.67 to 0.94)
CI: confidence interval.