| Two weeks of AmBd + FLU + steroids compared to two weeks of AmBd + FLU for HIV‐associated cryptococcal meningitis |
|
Patient or population: HIV‐infected individual with first episode of cryptococcal meningitis
Setting: randomized controlled trial
Intervention: 2 weeks of AmBd + FLU + steroids
Comparison: 2 weeks of AmBd + FLU |
| Outcomes |
Anticipated absolute effects* (95% CI) |
Relative effect
(95% CI) |
Number of participants
(trials) |
Certainty of the evidence
(GRADE) |
| Risk with 2 weeks of AmBd + FLU |
Risk with 2 weeks of AmBd + FLU + steroids |
| Mortality: 10 weeks |
412 per 1000 |
473 per 1000
(383 to 584) |
RR 1.15
(0.93 to 1.42) |
450
(1 RCT) |
⊕⊕⊕⊕
HIGH |
| *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
Abbreviations: AmBd: amphotericin B deoxycholate; CI: confidence interval; FLU: fluconazole; RCT: randomized controlled trial; RR: risk ratio |
|
GRADE Working Group grades of evidence
High certainty: we are very confident that the true effect lies close to that of the estimate of the effect.
Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect.
Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. |
