Summary of findings 19. Two weeks of AmBd + 5FC + FLU compared to two weeks of AmBd for HIV‐associated cryptococcal meningitis.

Two weeks of AmBd + 5FC + FLU compared to two weeks of AmBd for HIV‐associated cryptococcal meningitis
Patient or population: HIV‐infected individual with first episode of cryptococcal meningitis Setting: randomized controlled trial Intervention: 2 weeks of AmBd + 5FC + FLU Comparison: 2 weeks of AmBd
Outcomes	Anticipated absolute effects* (95% CI)		Relative effect (95% CI)	№ of participants (studies)	Certainty of the evidence (GRADE)
	Risk with 2 weeks of AmBd	Risk with 2 weeks of AmBd + 5FC + FLU
Mortality: 10 weeks	188 per 1000	188 per 1000 (45 to 793)	RR 1.00 (0.24 to 4.23)	32 (1 RCT)	⊕⊝⊝⊝ VERY LOW1,2
*The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). Abbreviations: 5FC: flucytosine; AmBd: amphotericin B deoxycholate; CI: confidence interval; FLU: fluconazole; RCT: randomized controlled trial; RR: risk ratio
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

¹Downgraded one level for indirectness. Data generated from a single study that used a low dose of fluconazole.
 ²Downgraded two levels for imprecision. Data from a single small study with few events and broad CI including appreciable benefit and appreciable harm.