Comparison 1. One week of AmBd + 5FC versus two weeks of AmBd + 5FC.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 2 weeks	1	228	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.30, 1.03]
1.2 10 weeks	1	228	Risk Ratio (M‐H, Random, 95% CI)	0.62 [0.42, 0.93]
2 Early fungicidal activity	1	186	Mean Difference (IV, Random, 95% CI)	0.05 [‐0.02, 0.12]
3 DAIDS grade 3/4 toxicities	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Anaemia	1	228	Risk Ratio (M‐H, Random, 95% CI)	0.31 [0.16, 0.60]
3.2 Renal dysfunction	1	228	Risk Ratio (M‐H, Random, 95% CI)	0.58 [0.18, 1.93]
3.3 Neutropenia	1	228	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.43, 2.03]
3.4 Hypokalaemia	1	228	Risk Ratio (M‐H, Random, 95% CI)	1.31 [0.50, 3.39]
3.5 ALT abnormality	1	228	Risk Ratio (M‐H, Random, 95% CI)	3.05 [0.63, 14.81]