Comparison 5. Two weeks of 5FC + FLU versus two weeks of AmBd + 5FC.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 2 weeks	1	340	Risk Ratio (M‐H, Random, 95% CI)	0.87 [0.56, 1.37]
1.2 10 weeks	1	340	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.69, 1.23]
2 Early fungicidal activity	1	270	Mean Difference (IV, Random, 95% CI)	0.23 [0.17, 0.29]
3 DAIDS grade 3/4 toxicities	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Anaemia	1	340	Risk Ratio (M‐H, Random, 95% CI)	0.17 [0.09, 0.32]
3.2 Renal dysfunction	1	340	Risk Ratio (M‐H, Random, 95% CI)	0.80 [0.32, 2.02]
3.3 Neutropenia	1	340	Risk Ratio (M‐H, Random, 95% CI)	0.98 [0.51, 1.90]
3.4 Hypokalaemia	1	340	Risk Ratio (M‐H, Random, 95% CI)	0.22 [0.06, 0.83]
3.5 ALT abnormality	1	340	Risk Ratio (M‐H, Random, 95% CI)	1.53 [0.31, 7.48]