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. 2018 Jul 25;2018(7):CD005647. doi: 10.1002/14651858.CD005647.pub3

Comparison 14. Two weeks of FLU versus two weeks of 5FC + FLU.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Mortality 2   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.1 2 weeks 2 98 Risk Ratio (M‐H, Random, 95% CI) 3.04 [1.31, 7.06]
1.2 10 weeks 2 98 Risk Ratio (M‐H, Random, 95% CI) 1.46 [0.96, 2.23]
2 Early fungicidal activity 1 37 Mean Difference (IV, Random, 95% CI) 0.17 [0.08, 0.26]
3 DAIDS grade 3/4 toxicities 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
3.1 Anaemia 1 40 Risk Ratio (M‐H, Random, 95% CI) 1.11 [0.07, 16.47]
3.2 Renal dysfunction 1 40 Risk Ratio (M‐H, Random, 95% CI) 2.21 [0.22, 22.47]
3.3 Neutropenia 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.22 [0.03, 1.73]
3.4 ALT abnormality 1 40 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]