NCT01802385.

Trial name or title	Adjunctive sertraline for the treatment of HIV‐associated cryptococcal meningitis (ASTRO‐CM)
Methods	Phase 3 RCT
Participants	≥ 18 years of age with HIV‐associated cryptococcal meningitis
Interventions	2 weeks of AmBd 0.7 to 1.0 mg/kg/day and FLU 800 to 1200 mg/day plus sertraline 400 mg/day for 2 weeks then sertraline 200 mg/day for 12 weeks then tapered over 3 weeks versus 2 weeks of AmBd 0.7 to 1.0 mg/kg/day and FLU 800 to 1200 mg/day
Outcomes	Primary: 18‐week survival
Starting date	2015
Contact information	david.meya@gmail.com
Notes	Study terminated during interim monitoring for futility, results not published in peer‐reviewed journal but presented at Conference on Retroviruses and Opportunistic Infections 2018.

Abbreviations: 5FC: flucytosine; AmBd: amphotericin B deoxycholate; CSF: cerebrospinal fluid; FLU: fluconazole; IV: intravenous; L‐AmB: liposomal amphotericin; RCT: randomized controlled trial