Date	Event	Description
31 July 2018	New search has been performed	A search of the Cystic Fibrosis and Genetic Disorders Review Group's Cystic Fibrosis Trials Register identified seven new references potentially eligible for inclusion in the review. One reference has been added to the already included study (Quan 2001). One reference has been added to the already excluded study (Mainz 2014). On closer inspection, it became clear that the abstract by Middleton et al previously listed under an excluded study (Fitzgerald 2005) is an additional reference to a published full paper identified and excluded at this search (Bishop 2011). Both the Middleton abstract and the full paper are now listed under the excluded study ID (Bishop 2011). One further new study with three references has been excluded (van der Giessen 2007b) as has one study with a single reference (Kelijo 2001). We undertook additional searches of ClinicalTrials.gov and the International Clinical Trials Registry Platform. Of the 18 trials identified on ClincalTrials.gov, seven trials were already included in this review (Amin 2011; Castile 2009; Freemer 2010; Lahiri 2012; Mainz 2014; Minasian 2010; Sawicki 2014). The remaining 11 trials were excluded (Bilton 2011; Mainz 2011; NCT00311506; NCT00434278; NCT00843817; NCT01025258; NCT01155752; NCT01232478; NCT02301377; NCT02682290; NCT02722122). Of the five trials identified on the International Clinical Trials Registry Platform, one was a duplicate of a trial identified on ClinicalTrials.gov (NCT02722122) and a further two trials were already included in this review (Diot 2009; Minasian 2010). The remaining two trials were excluded (EUCTR2006‐002098‐30‐NL; EUCTR2007‐000935‐25‐NL).
31 July 2018	New citation required but conclusions have not changed	No new data have been added to the review, therefore our conclusions remain the same. Sarah Nolan and Mark Chilvers have stepped down from the author team.