Adler 2004.

Methods	Randomised trial
Participants	533 patients with depression and/or dysthymia (intervention: 268; control: 265) . 9 Eastern Massachusetts primary care practices USA Year of study: Not stated.
Interventions	Pharmacists assessed a range of variables; medication history, medication regimen for drug issues, drug efficacy and toxicity, education about depression including symptoms and antidepressants, encouraged anti‐depressant therapy and maintained strong therapeutic communication with patients. This was tailored towards the patient's needs in accordance with depression guidelines. Pharmacists spent 70 minutes per patient across a 6‐month period; minimal intervention was to be 9 appointments over 18 months.
Outcomes	Modified Beck Depression Inventory (mBDI) at 6 months
Notes	Funding source: National Institute of Mental Health under grant RO1 MH56214 Conflict of interest: None stated.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomised by a "computerised coin‐flip" built into the screener
Allocation concealment (selection bias)	Low risk	Randomisation is post‐enrolment
Blinding of participants and personnel (performance bias) All Outcomes/Outcome 1	High risk	Outcome are self‐reported and no blinding of personnel or participants
Blinding of outcome assessment (detection bias) All Outcomes/Outcome 1	High risk	Non‐blinded patients acted as their own assessors.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Between group attrition < 10%.
Selective reporting (reporting bias)	Low risk	All outcomes reported
Other bias	Low risk	None identified