Charrois 2006.

Methods	Randomised trial
Participants	71 participants with high‐risk asthma (intervention 37; control 34) Community pharmacies in 2 remote rural communities Alberta, Canada Year of study: Not stated.
Interventions	Intervention patients received education on asthma (medications, inhaler technique, written asthma education materials and development of action plan), Optimisation of drug therapy and assessment of adherence with formal onward referral as needed to respiratory therapist or physician Follow‐up at 2 weeks by telephone call and at 1, 2, 4 and 6 months Duration: 6 months
Outcomes	Number of hospitalisations, Asthma Control Questionaire
Notes	Funding source: Canadian Institutes of Health Research, Institute of Health Economics, University Hospital Foundation, and ASTHMA Study (Alberta Strategy to Help Manage Asthma) Conflict of interest: Not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	The patient is randomised by an internet randomisation service through the Epidemiology Coordinating and Research (EPICORE) Centre, University of Alberta.
Allocation concealment (selection bias)	Low risk	As 2 sites did not have internet access, sealed envelopes are provided for randomisation. To help ensure balance, randomisation was done in blocks of 6 and stratified by site.
Blinding of participants and personnel (performance bias) All Outcomes/Outcome 1	High risk	Performance of usual care may have been influenced by intervention.
Blinding of outcome assessment (detection bias) All Outcomes/Outcome 1	Low risk	Hospitalisation is an objective measure.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Between group attrition > 10%, however, intention‐to‐treat analysis seems to have been undertaken.
Selective reporting (reporting bias)	Low risk	Main outcome measures reported
Other bias	Unclear risk	Contamination of the usual‐care group may have occurred, as the caregivers involved in the study were not blinded. As part of the study implementation, we met with all local physicians.