Di Donato 2014.
| Methods | Randomised trial | |
| Participants | 302 participants with hypertension (number per group not stated) Community pharmacy chain stores USA Year of study: January 2012 to June 2012 |
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| Interventions | Pharmacists synchronised all medication (re)fills, including antihypertensive medication(s), prior to the date when the next refill was due and pharmacists checked for any medication changes. At the point of refill pharmacists measured patient blood pressure. Duration: 4 months |
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| Outcomes | Systolic blood pressure Diastolic blood pressure % within target blood pressure |
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| Notes | Funding source: The Red Cross Pharmacy Residency Program is funded by a Community Pharmacy Residency Expansion Project grant from the National Association of Chain Drug Stores Foundation. This study was supported by HoMedics, Inc. through product donation. Conflict of interest: None stated |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | High risk | Quote: "Patients were enrolled at six retail locations and randomized by research staff into three groups based on enrollment order: control, medication synchronization, or education". This may be less effective than true random allocation. |
| Allocation concealment (selection bias) | High risk | Quote: "Patients were enrolled at six retail locations and randomized by research staff into three groups based on enrollment order: control, medication synchronization, or education. Randomization occurred at the patient level, and within each pharmacy. " Investigators could foresee assignment: |
| Blinding of participants and personnel (performance bias) All Outcomes/Outcome 1 | Low risk | Most of the outcomes were objective and should be immune to strong bias. |
| Blinding of outcome assessment (detection bias) All Outcomes/Outcome 1 | Low risk | Used an electronic blood pressure measure |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Statistical analyses were conducted by a 'per protocol' approach (i.e. patients lost to follow‐up were excluded). Between group attrition < 10%. |
| Selective reporting (reporting bias) | Low risk | Main outcomes reported |
| Other bias | Low risk | None |